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Pentobarbital was used in a U.S. execution for The 1st time in December 2010 in Oklahoma, as Portion of A 3-drug protocol.[sixteen] In March 2011 pentobarbital was used for The very first time as the only drug within a U.S. execution, in Ohio. Due to the fact then many states in addition to the federal govt have applied pentobarbital for lethal inj